Xorel 20mg Capsule contains Rabeprazole Sodium is used to relieve acidity and heartburn in conditions such as stomach and intestinal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison Syndrome.
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Xorel 20mg Capsule contains Rabeprazole, which belongs to the group of medicines called Proton pump inhibitors. It is commonly used to treat conditions such as Gastro-esophageal Reflux Disease (GERD), peptic ulcer, and Zollinger-Ellison syndrome. GERD is a chronic digestive disease where stomach acid flows back into the esophagus, causing irritation. Peptic ulcers are painful sores that can develop in the stomach, esophagus, or intestines.
Xorel 20mg Capsule is usually taken before meals or as directed by a physician. It's important to follow the dosage instructions provided by your doctor or as mentioned on the medication packaging.
Before taking Xorel 20mg Capsule, it is important to inform your doctor if you have any liver problems. Additionally, inform your doctor if you have vitamin B12 deficiency, osteoporosis, or any tumors in your stomach. This information will help your doctor make informed decisions about your treatment plan.
It is important to consult your doctor before taking Xorel 20mg Capsule if you are pregnant or breastfeeding. The safety of the medication during pregnancy and lactation has not been well established, and your doctor can provide guidance on the potential risks and benefits.
It is important to notify your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after taking Xorel 20mg Capsules. This could be a sign of a more serious condition that requires medical attention.
Avoid consumption of alcohol while taking Xorel 20mg Capsule. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Xorel 20mg Capsule is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
Xorel 20mg Capsule is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Xorel 20mg Capsule may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Xorel 20mg Capsule should be used with caution in patients who have or ever had any liver problems. Therefore, consult your doctor before taking it.
Xorel 20mg Capsule is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances of acid reflux into the esophagus, heals peptic ulcers and esophageal lesions, and prevents its recurrence.
The most well-known utilization of Xorel 20mg Capsul is
Rabeprazole reduces gastric acid production by inhibiting the gastric H+/K+-ATPase at the secretory membrane of the gastric parietal cell. Because this enzyme is thought to be the acid (proton) pump within the parietal cell, rabeprazole has been classified as a gastric proton-pump inhibitor.
Adult Dose:
Child Dose:
Delayed-release capsule (sprinkles):
Delayed-release tablet:
12 years: 20mg once daily for up to 8 weeks.
Renal Dose:
Please note that this dosage information is a general guideline, and individual dosing may vary based on factors such as the patient's condition, response to treatment, and the prescribing physician's judgment. Always follow your doctor's instructions and consult with them for personalized dosage recommendations specific to your situation.
Administration:
Follow your physician's advice: Take Xorel 20mg Capsule as advised by your physician. They will determine the appropriate dose and duration of therapy based on factors such as your age, body weight, and the specific condition being treated.
Swallow with water: Take the tablet with a glass of water. Do not crush or chew the tablet, as it is meant to be swallowed whole.
Timing of administration: Xorel 20mg Capsule is preferably taken in the mornings or at any time of the day before meals. This timing may help optimize its effectiveness in treating the conditions it is prescribed for.
Drug-Food Interactions: It is advised to avoid smoking and alcohol consumption while taking Xorel 20mg Capsules. Alcohol intake can increase the production of stomach acid, leading to increased acidity and heartburn. Smoking can also worsen gastroesophageal reflux disease (GERD) symptoms.
Drug-Disease Interactions: Inform your doctor if you have the following conditions:
Rabeprazole is contraindicated in patients with known hypersensitivity to Rabeprazole, other PPIs, or any formulation component.
there are no available human data on the use ofXorel 20mg Capsule in pregnant women. The potential risk associated with its use during pregnancy is unknown. It's important to note that the background risk of major birth defects and miscarriage in the general population is estimated to be 2-4% and 15-20% of clinically recognized pregnancies, respectively.
Animal reproduction studies with rabeprazole (the active ingredient in Xorel 20mg Capsule) did not show evidence of adverse developmental effects when administered during organogenesis at doses 13 and 8 times the human area under the plasma concentration-time curve (AUC) at the recommended dose for GERD in rats and rabbits, respectively.
However, in animal studies, changes in bone morphology were observed in the offspring of rats treated with oral doses of different proton pump inhibitors (PPIs) throughout pregnancy and lactation. When the maternal administration of PPIs was confined to gestation only, there were no effects on bone physeal morphology in offspring at any age.
Considering the limited data available, it is important to consult with your healthcare provider before using Xorel 20mg Capsule during pregnancy. They can evaluate the potential benefits and risks and provide guidance based on your specific situation.
It's also important to discuss any pregnancy plans or ongoing pregnancy with your healthcare provider to ensure appropriate monitoring and management.
Store in a cool and dry place, and protect from light.
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